SYRENasdaq

Spyre Therapeutics, Inc.

Alert me on SYRE

Insider buys, 6 months

Congress trades, 6 months

Signals, 6 months

Six months

After each filing

Oct 3 Sale King-Jones Heidy Insider

1 week

−7.4%S&P +0.4%

1 month

+7.1%S&P −2.6%

3 months

Result in38 trading days

6 months

Result in101 trading days

Oct 3 Sale Burrows Scott L Insider

1 week

−7.4%S&P +0.4%

1 month

+7.1%S&P −2.6%

3 months

Result in38 trading days

6 months

Result in101 trading days

Oct 3 Sale Turtle Cameron Insider

1 week

−7.4%S&P +0.4%

1 month

+7.1%S&P −2.6%

3 months

Result in38 trading days

6 months

Result in101 trading days

Sep 4 Sale Turtle Cameron Insider

1 week

+2.0%S&P −1.2%

1 month

−10.0%S&P +1.4%

3 months

Result in18 trading days

6 months

Result in81 trading days

Sep 4 Sale Burrows Scott L Insider

1 week

+2.0%S&P −1.2%

1 month

−10.0%S&P +1.4%

3 months

Result in18 trading days

6 months

Result in81 trading days

Show all 35

Sep 4 Sale King-Jones Heidy Insider

1 week

+2.0%S&P −1.2%

1 month

−10.0%S&P +1.4%

3 months

Result in18 trading days

6 months

Result in81 trading days

Aug 11 Sale Albers Jeffrey W. Insider

1 week

+4.9%S&P −0.4%

1 month

−13.7%S&P −1.7%

3 months

+6.1%S&P −2.1%

6 months

Result in63 trading days

Aug 6 Sale Turtle Cameron Insider

1 week

−1.5%S&P +1.2%

1 month

−14.0%S&P +0.2%

3 months

−4.2%S&P 0.0%

6 months

Result in60 trading days

Aug 6 Sale Burrows Scott L Insider

1 week

−1.5%S&P +1.2%

1 month

−14.0%S&P +0.2%

3 months

−4.2%S&P 0.0%

6 months

Result in60 trading days

Jul 3 Sale Sloan Sheldon Insider

1 week

+5.6%S&P −0.3%

1 month

+18.3%S&P +2.7%

3 months

+5.0%S&P +2.7%

6 months

Result in37 trading days

Jul 3 Sale Turtle Cameron Insider

1 week

+5.6%S&P −0.3%

1 month

+18.3%S&P +2.7%

3 months

+5.0%S&P +2.7%

6 months

Result in37 trading days

Jul 3 Sale Burrows Scott L Insider

1 week

+5.6%S&P −0.3%

1 month

+18.3%S&P +2.7%

3 months

+5.0%S&P +2.7%

6 months

Result in37 trading days

Jun 27 Sale Burrows Scott L Insider

1 week

+4.5%S&P +0.9%

1 month

+8.6%S&P −1.6%

3 months

−4.8%S&P +3.6%

6 months

Result in33 trading days

Jun 24 Sale Fairmount Funds Management LLC Insider

1 week

+3.1%S&P +1.7%

1 month

+18.4%S&P +0.8%

3 months

+2.2%S&P +5.0%

6 months

Result in30 trading days

Jun 24 Sale Fairmount Healthcare Fund II L.P. Insider

1 week

+3.1%S&P +1.7%

1 month

+18.4%S&P +0.8%

3 months

+2.2%S&P +5.0%

6 months

Result in30 trading days

Jun 24 Sale Kiselak Tomas Insider

1 week

+3.1%S&P +1.7%

1 month

+18.4%S&P +0.8%

3 months

+2.2%S&P +5.0%

6 months

Result in30 trading days

Jun 24 Sale Harwin Peter Evan Insider

1 week

+3.1%S&P +1.7%

1 month

+18.4%S&P +0.8%

3 months

+2.2%S&P +5.0%

6 months

Result in30 trading days

Jun 24 Sale HENDERSON MICHAEL THOMAS Insider

1 week

+3.1%S&P +1.7%

1 month

+18.4%S&P +0.8%

3 months

+2.2%S&P +5.0%

6 months

Result in30 trading days

Jun 4 Sale Sloan Sheldon Insider

1 week

+2.9%S&P −2.6%

1 month

+20.1%S&P −1.0%

3 months

+11.2%S&P +2.4%

6 months

Result in17 trading days

Jun 4 Sale Turtle Cameron Insider

1 week

+2.9%S&P −2.6%

1 month

+20.1%S&P −1.0%

3 months

+11.2%S&P +2.4%

6 months

Result in17 trading days

Jun 4 Sale Burrows Scott L Insider

1 week

+2.9%S&P −2.6%

1 month

+20.1%S&P −1.0%

3 months

+11.2%S&P +2.4%

6 months

Result in17 trading days

May 9 Sale HENDERSON MICHAEL THOMAS Insider

1 week

−8.3%S&P −0.1%

1 month

−1.8%S&P −1.9%

3 months

+34.4%S&P +4.5%

6 months

+42.6%S&P +2.3%

May 2 Sale Turtle Cameron Insider

1 week

+10.6%S&P +3.0%

1 month

+6.4%S&P +5.0%

3 months

+51.8%S&P +7.7%

6 months

+38.2%S&P +5.3%

May 2 Sale Sloan Sheldon Insider

1 week

+10.6%S&P +3.0%

1 month

+6.4%S&P +5.0%

3 months

+51.8%S&P +7.7%

6 months

+38.2%S&P +5.3%

May 2 Sale Burrows Scott L Insider

1 week

+10.6%S&P +3.0%

1 month

+6.4%S&P +5.0%

3 months

+51.8%S&P +7.7%

6 months

+38.2%S&P +5.3%

Apr 4 Sale Sloan Sheldon Insider

1 week

+29.2%S&P +4.1%

1 month

+45.0%S&P +9.8%

3 months

+92.4%S&P +13.8%

6 months

+89.3%S&P +18.2%

Apr 4 Sale Turtle Cameron Insider

1 week

+29.2%S&P +4.1%

1 month

+45.0%S&P +9.8%

3 months

+92.4%S&P +13.8%

6 months

+89.3%S&P +18.2%

Apr 4 Sale Burrows Scott L Insider

1 week

+29.2%S&P +4.1%

1 month

+45.0%S&P +9.8%

3 months

+92.4%S&P +13.8%

6 months

+89.3%S&P +18.2%

Mar 4 Sale Burrows Scott L Insider

1 week

+1.2%S&P −1.3%

1 month

+16.0%S&P −4.0%

3 months

+79.3%S&P +10.4%

6 months

+112.3%S&P +12.3%

Mar 4 Sale Turtle Cameron Insider

1 week

+1.2%S&P −1.3%

1 month

+16.0%S&P −4.0%

3 months

+79.3%S&P +10.4%

6 months

+112.3%S&P +12.3%

Feb 5 Sale Turtle Cameron Insider

1 week

+5.8%S&P +0.5%

1 month

+24.7%S&P +0.1%

3 months

+121.9%S&P +8.3%

6 months

+218.5%S&P +14.7%

Jan 7 Sale Turtle Cameron Insider

1 week

+6.8%S&P +0.1%

1 month

+13.1%S&P +0.2%

3 months

+66.7%S&P −1.1%

6 months

+214.8%S&P +10.1%

Dec 4, 2025 Sale Turtle Cameron Insider

1 week

+2.5%S&P +0.7%

1 month

−9.5%S&P +1.4%

3 months

+22.6%S&P −0.6%

6 months

+114.9%S&P +8.6%

Nov 6, 2025 Sale Turtle Cameron Insider

1 week

+1.1%S&P +0.3%

1 month

+54.7%S&P +2.0%

3 months

+51.7%S&P +3.8%

6 months

+241.4%S&P +10.9%

Sep 4, 2025 Sale Burrows Scott L Insider

1 week

−4.6%S&P +1.3%

1 month

−6.5%S&P +3.4%

3 months

+89.5%S&P +5.6%

6 months

+136.3%S&P +4.2%

Every purchase and sale on this ticker reported by a member of Congress or an insider, measured from the close of the first trading day after it became public to the close 1 week, 1 month, 3 months and 6 months later, each beside the S&P over the same days.

Filings for SYRE

72 held · newest 572 held · newest 2

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See all 72 filings for SYRE

Aeon news and offers by email

New sources, new features and offers like our founding price. A few times a month at most. Stop any time.

Signal history

No signal for this ticker yet. A signal is written when insider buying here scores one dot or more.

Stakes

Oct 7, 2026 Schedule 13D, amended

Harwin Peter Evan: 10%, 10,185,961 shares

Sep 24, 2026 Schedule 13G

Paradigm BioCapital Advisors LP: 5.1%, 4,457,450 shares

Jun 30, 2026 Schedule 13G, amended

Perceptive Advisors LLC: 4.9%, 4,319,496 shares

Jun 30, 2026 Schedule 13G, amended

RTW Investments, LP: 4.8%, 4,251,996 shares

Jun 23, 2026 Schedule 13D, amended

Peter Evan Harwin: 10%, 9,667,201 shares

Apr 15, 2026 Schedule 13G

Perceptive Advisors LLC: 5%, 4,319,496 shares

Apr 16, 2026 Schedule 13D, amended

Peter Harwin: 10%, 9,016,702 shares

Mar 13, 2026 Schedule 13G, amended

The Vanguard Group: 0%, 0 shares

Dec 31, 2025 Schedule 13G, amended

TANG CAPITAL MANAGEMENT, LLC: 2.4%, 1,892,200 shares

Oct 15, 2025 Schedule 13D, amended

Peter Evan Harwin: 10%, 8,106,882 shares

Schedule 13D is filed within 5 business days of crossing 5 percent by an investor who may seek to influence the company. Schedule 13G is filed by a passive holder, and a large institution has up to 45 days after the quarter end.

Government contracts, last 12 months

Awards of $10M and up, from USAspending · context, not a signal

No contracts of $10M or more in the last 12 months.

Lobbying

Last four quarters

$10KQ4 2025

$40KQ1 2026

$10KQ2 2026

$10KQ3 2026

Unchanged from Q2 2026. Reported to the Senate each quarter by the firms it hires.Original report ↗

Read from LDA.gov between Sep 23, 2026 and Oct 20, 2026. Senate Office of Public Records cannot vouch for the data or analyses derived from these data after the data have been retrieved from LDA.gov.