KPTINasdaq

Karyopharm Therapeutics Inc.

Alert me on KPTI

Insider buys, 6 months

Congress trades, 6 months

Signals, 6 months

Six months

After each filing

Oct 20 Sale Abate Kristin Insider

1 week

+33.9%S&P +0.1%

1 month

Result in7 trading days

3 months

Result in49 trading days

6 months

Result in112 trading days

Oct 3 Sale Abate Kristin Insider

1 week

−24.7%S&P +0.4%

1 month

−86.8%S&P −2.6%

3 months

Result in38 trading days

6 months

Result in101 trading days

Sep 3 Sale Abate Kristin Insider

1 week

−9.0%S&P −1.1%

1 month

−62.1%S&P +0.5%

3 months

Result in17 trading days

6 months

Result in80 trading days

Jul 31 Sale Poulton Stuart Insider

1 week

+10.4%S&P +3.5%

1 month

+7.3%S&P +2.7%

3 months

−54.2%S&P +3.2%

6 months

Result in56 trading days

May 16 Sale Poulton Stuart Insider

1 week

+25.6%S&P +1.6%

1 month

+31.7%S&P +0.3%

3 months

−73.0%S&P +4.2%

6 months

Result in5 trading days

Show all 29

May 16 Sale Rangwala Reshma Insider

1 week

+25.6%S&P +1.6%

1 month

+31.7%S&P +0.3%

3 months

−73.0%S&P +4.2%

6 months

Result in5 trading days

May 16 Sale Paulson Richard A. Insider

1 week

+25.6%S&P +1.6%

1 month

+31.7%S&P +0.3%

3 months

−73.0%S&P +4.2%

6 months

Result in5 trading days

May 16 Sale Cheng Sohanya Roshan Insider

1 week

+25.6%S&P +1.6%

1 month

+31.7%S&P +0.3%

3 months

−73.0%S&P +4.2%

6 months

Result in5 trading days

May 16 Sale Mano Michael Insider

1 week

+25.6%S&P +1.6%

1 month

+31.7%S&P +0.3%

3 months

−73.0%S&P +4.2%

6 months

Result in5 trading days

May 16 Sale Abate Kristin Insider

1 week

+25.6%S&P +1.6%

1 month

+31.7%S&P +0.3%

3 months

−73.0%S&P +4.2%

6 months

Result in5 trading days

Apr 23 Sale Rangwala Reshma Insider

1 week

−5.0%S&P +1.4%

1 month

−6.7%S&P +5.2%

3 months

−15.3%S&P +4.6%

6 months

−93.8%S&P +8.4%

Mar 4 Sale Rangwala Reshma Insider

1 week

−4.4%S&P −1.3%

1 month

−35.6%S&P −4.0%

3 months

−1.6%S&P +10.4%

6 months

−80.4%S&P +12.3%

Mar 4 Sale Cheng Sohanya Roshan Insider

1 week

−4.4%S&P −1.3%

1 month

−35.6%S&P −4.0%

3 months

−1.6%S&P +10.4%

6 months

−80.4%S&P +12.3%

Mar 4 Sale Poulton Stuart Insider

1 week

−4.4%S&P −1.3%

1 month

−35.6%S&P −4.0%

3 months

−1.6%S&P +10.4%

6 months

−80.4%S&P +12.3%

Mar 4 Sale Paulson Richard A. Insider

1 week

−4.4%S&P −1.3%

1 month

−35.6%S&P −4.0%

3 months

−1.6%S&P +10.4%

6 months

−80.4%S&P +12.3%

Mar 4 Sale Mano Michael Insider

1 week

−4.4%S&P −1.3%

1 month

−35.6%S&P −4.0%

3 months

−1.6%S&P +10.4%

6 months

−80.4%S&P +12.3%

Mar 4 Sale Abate Kristin Insider

1 week

−4.4%S&P −1.3%

1 month

−35.6%S&P −4.0%

3 months

−1.6%S&P +10.4%

6 months

−80.4%S&P +12.3%

Feb 20 Sale Poulton Stuart Insider

1 week

−2.7%S&P −0.5%

1 month

−31.1%S&P −4.7%

3 months

−16.6%S&P +8.0%

6 months

−79.7%S&P +11.7%

Feb 5 Sale Macomber Lori Insider

1 week

+46.8%S&P +0.5%

1 month

+39.4%S&P +0.1%

3 months

+45.3%S&P +8.3%

6 months

−65.2%S&P +14.7%

Jan 30 Sale Abate Kristin Insider

1 week

−4.0%S&P −0.2%

1 month

+40.0%S&P −1.7%

3 months

+34.5%S&P +4.4%

6 months

−69.8%S&P +10.1%

Jan 23 Sale Abate Kristin Insider

1 week

−1.1%S&P +0.4%

1 month

+52.8%S&P −0.3%

3 months

+31.4%S&P +3.9%

6 months

+7.6%S&P +7.8%

Oct 4, 2025 Sale Abate Kristin Insider

1 week

−8.8%S&P −1.3%

1 month

−8.3%S&P +0.5%

3 months

+19.3%S&P +3.3%

6 months

+17.7%S&P +1.2%

Sep 17, 2025 Sale Abate Kristin Insider

1 week

+13.2%S&P +0.6%

1 month

−0.8%S&P +0.5%

3 months

+4.1%S&P +3.3%

6 months

+27.1%S&P +0.7%

Sep 17, 2025 Sale Cheng Sohanya Roshan Insider

1 week

+13.2%S&P +0.6%

1 month

−0.8%S&P +0.5%

3 months

+4.1%S&P +3.3%

6 months

+27.1%S&P +0.7%

Sep 17, 2025 Sale Paulson Richard A. Insider

1 week

+13.2%S&P +0.6%

1 month

−0.8%S&P +0.5%

3 months

+4.1%S&P +3.3%

6 months

+27.1%S&P +0.7%

Sep 17, 2025 Sale Rangwala Reshma Insider

1 week

+13.2%S&P +0.6%

1 month

−0.8%S&P +0.5%

3 months

+4.1%S&P +3.3%

6 months

+27.1%S&P +0.7%

Sep 17, 2025 Sale Mano Michael Insider

1 week

+13.2%S&P +0.6%

1 month

−0.8%S&P +0.5%

3 months

+4.1%S&P +3.3%

6 months

+27.1%S&P +0.7%

Sep 17, 2025 Sale Poulton Stuart Insider

1 week

+13.2%S&P +0.6%

1 month

−0.8%S&P +0.5%

3 months

+4.1%S&P +3.3%

6 months

+27.1%S&P +0.7%

Sep 5, 2025 Sale Abate Kristin Insider

1 week

−2.3%S&P +1.6%

1 month

−6.7%S&P +4.1%

3 months

−10.5%S&P +6.0%

6 months

+28.6%S&P +5.4%

Every purchase and sale on this ticker reported by a member of Congress or an insider, measured from the close of the first trading day after it became public to the close 1 week, 1 month, 3 months and 6 months later, each beside the S&P over the same days.

Filings for KPTI

78 held · newest 578 held · newest 2

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See all 78 filings for KPTI

Aeon news and offers by email

New sources, new features and offers like our founding price. A few times a month at most. Stop any time.

Signal history

No signal for this ticker yet. A signal is written when insider buying here scores one dot or more.

Stakes

Sep 30, 2026 Schedule 13G, amended

THE GOLDMAN SACHS GROUP, INC.: 0.9%, 203,129 shares

Sep 30, 2026 Schedule 13G, amended

Integrated Core Strategies (US) LLC: 0.2%, 42,888 shares

Oct 2, 2026 Schedule 13G, amended

Anders Hove: 4.5%, 1,021,668 shares

Sep 22, 2026 Schedule 13G, amended

Anders Hove: 5.7%, 1,284,221 shares

Sep 22, 2026 Schedule 13G, amended

Anders Hove: 5.7%, 1,284,221 shares

Aug 31, 2026 Schedule 13G

Integrated Core Strategies (US) LLC: 5.7%, 1,297,297 shares

Jun 30, 2026 Schedule 13G, amended

RA Capital Management, L.P.: 9.9%, 2,302,504 shares

Jun 30, 2026 Schedule 13G, amended

Commodore Capital LP: 0%, 0 shares

Jun 30, 2026 Schedule 13G, amended

Adage Capital Management, L.P.: 6.8%, 1,536,736 shares

Jun 30, 2026 Schedule 13G, amended

THE GOLDMAN SACHS GROUP, INC.: 6.3%, 1,429,198 shares

Jun 30, 2026 Schedule 13G

BlackRock, Inc.: 5.6%, 1,266,084 shares

May 31, 2026 Schedule 13G, amended

T. Rowe Price Investment Management, Inc.: 6.6%, 1,539,147 shares

Mar 31, 2026 Schedule 13G

Ikarian Capital, LLC: 0%, 0 shares

May 13, 2026 Schedule 13G

Anders Hove: 6.7%, 1,518,113 shares

Mar 31, 2026 Schedule 13G, amended

Affinity Asset Advisors, LLC: 8.6%, 2,073,517 shares

Mar 31, 2026 Schedule 13G

Adage Capital Management, L.P.: 8.1%, 1,821,736 shares

Mar 31, 2026 Schedule 13G

THE GOLDMAN SACHS GROUP, INC.: 5.1%, 991,364 shares

Mar 31, 2026 Schedule 13G, amended

Opaleye Management Inc.: 2.7%, 619,089 shares

Mar 31, 2026 Schedule 13G, amended

Millennium Management LLC: 2.3%, 511,571 shares

Mar 26, 2026 Schedule 13G

RA Capital Management, L.P.: 9.9%, 2,078,913 shares

Mar 26, 2026 Schedule 13G

Commodore Capital LP: 9.9%, 1,950,000 shares

Dec 31, 2025 Schedule 13G, amended

T. Rowe Price Investment Management, Inc.: 11.8%, 2,244,421 shares

Dec 31, 2025 Schedule 13G, amended

Adage Capital Management, L.P.: 2.4%, 436,736 shares

Feb 4, 2026 Schedule 13G

Millennium Management LLC: 5.5%, 1,008,662 shares

Jan 22, 2026 Schedule 13G, amended

Affinity Asset Advisors, LLC: 8.6%, 1,713,092 shares

Sep 30, 2025 Schedule 13G, amended

HIGHBRIDGE CAPITAL MANAGEMENT, LLC: 4.9%, 649,984 shares

Oct 31, 2025 Schedule 13G, amended

T. Rowe Price Investment Management, Inc.: 13.8%, 2,304,242 shares

Oct 14, 2025 Schedule 13G, amended

J. Wood Capital Advisors LLC: 5%, 1,000,708 shares

Sep 30, 2025 Schedule 13G, amended

The Vanguard Group: 4.7%, 408,222 shares

Oct 10, 2025 Schedule 13G

Opaleye Management Inc.: 9.5%, 1,569,002 shares

Sep 30, 2025 Schedule 13G, amended

JPMORGAN CHASE & CO.: 4.9%, 427,624 shares

Schedule 13D is filed within 5 business days of crossing 5 percent by an investor who may seek to influence the company. Schedule 13G is filed by a passive holder, and a large institution has up to 45 days after the quarter end.

Government contracts, last 12 months

Awards of $10M and up, from USAspending · context, not a signal

No contracts of $10M or more in the last 12 months.

Lobbying

Last four quarters

$100KQ4 2025

NoneQ1 2026

NoneQ2 2026

NoneQ3 2026

Nothing on file for Q3 2026.

Read from LDA.gov on Sep 23, 2026. Senate Office of Public Records cannot vouch for the data or analyses derived from these data after the data have been retrieved from LDA.gov.